beta-Secretase Inhibitor II (Z-VLL-CHO), beta-secretase inhibitor (ab146640)

Overview

  • Product name

    beta-Secretase Inhibitor II (Z-VLL-CHO), beta-secretase inhibitor
  • Description

    Cell-permeable, reversible β-secretase inhibitor
  • Alternative names

    • Z-VLL-CHO
  • Biological description

    Cell-permeable, reversible β-secretase inhibitor. Corresponds to the VNL-DA cleavage site on APP. Inhibits Aβ formation (IC50 values are 0.7 and 2.5 µM for Aβtotal and Aβ1-42 respectively). Shows neuroprotective effects.
  • Purity

    > 95%
  • CAS Number

    263563-09-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]carbamate

  • Molecular weight

    461.60
  • Molecular formula

    C25H39N3O5
  • Sequence

    VVL (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde)
  • PubChem identifier

    10253763
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yoon SY  et al. zVLL-CHO at low concentrations acts as a calpain inhibitor to protect neurons against okadaic acid-induced neurodegeneration. Neurosci Lett 509:33-8 (2012). Read more (PubMed: 22230892) »
  • Nagai N  et al. Regulation of heparan sulfate 6-O-sulfation by beta-secretase activity. J Biol Chem 282:14942-51 (2007). Read more (PubMed: 17363373) »
  • Yamamoto R  et al. Neuroprotective effects of beta-secretase inhibitors against rat retinal ganglion cell death. Neurosci Lett 370:61-4 (2004). Read more (PubMed: 15489018) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146640.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up