Overview

  • Product name

    Anti-beta Synuclein antibody
    See all beta Synuclein primary antibodies
  • Description

    Mouse polyclonal to beta Synuclein
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog, Pig, Cynomolgus monkey, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Full length protein, corresponding to amino acids 1-134 of Human beta Synuclein (NP_001001502.1).

  • Positive control

    • beta Synuclein transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab167607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 14 kDa.

Target

  • Function

    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
  • Tissue specificity

    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
  • Sequence similarities

    Belongs to the synuclein family.
  • Post-translational
    modifications

    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • 14 kDa brain-specific protein antibody
    • Beta-synuclein antibody
    • Phosphoneuroprotein 14 antibody
    • PNP14 antibody
    • Sncb antibody
    • Synuclein beta antibody
    • SYUB_HUMAN antibody
    see all

Images

  • All lanes : Anti-beta Synuclein antibody (ab167607) at 1 µg/ml

    Lane 1 : beta Synuclein transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-Mouse IgG

    Predicted band size: 14 kDa

References

ab167607 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab167607.
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