Anti-beta Synuclein antibody, prediluted (ab15533)

Overview

  • Product name
    Anti-beta Synuclein antibody, prediluted
    See all beta Synuclein primary antibodies
  • Description
    Rabbit polyclonal to beta Synuclein, prediluted
  • Host species
    Rabbit
  • Specificity
    This antibody is specific for beta synuclein and does not cross react with alpha or gamma synuclein. Stains neuronal cytosol and presynaptic terminals.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Positive control
    • Brain.

Properties

Applications

Our Abpromise guarantee covers the use of ab15533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Ready to use for 10 minutes at room temperature. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    • Tissue specificity
      Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
    • Sequence similarities
      Belongs to the synuclein family.
    • Post-translational
      modifications
      Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 14 kDa brain-specific protein antibody
      • Beta-synuclein antibody
      • Phosphoneuroprotein 14 antibody
      • PNP14 antibody
      • Sncb antibody
      • Synuclein beta antibody
      • SYUB_HUMAN antibody
      see all

    Images

    • ab15533 staining beta Synuclein in human brain by Immunohistochemistry (FFPE-sections).

    References

    ab15533 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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