Betahistine dihydrochloride, H1 receptor agonist and H3 receptor antagonist (ab143334)

Overview

  • Product name

    Betahistine dihydrochloride, H1 receptor agonist and H3 receptor antagonist
  • Description

    Competitive partial H1 receptor agonist and H3 receptor antagonist
  • Biological description

    Competitive partial H1 receptor agonist (Ki = 31 μM) and H3 receptor antagonist. Histamine (ab120734) analog. Increases cochlear blood flow in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    5579-84-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Methyl-2-pyridin-2-ylethanamine dihydrochloride
  • Molecular weight

    209.12
  • Molecular formula

    C8H12N2.2HCl
  • PubChem identifier

    68643
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(C=CC=CN=1)CCNC.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ihler F  et al. Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo. PLoS One 7:e39086 (2012). Read more (PubMed: 22745706) »
  • Gbahou F  et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. J Pharmacol Exp Ther 334:945-54 (2010). Read more (PubMed: 20530654) »
  • Arrang JM  et al. Actions of betahistine at histamine receptors in the brain. Eur J Pharmacol 111:73-84 (1985). Read more (PubMed: 2990946) »

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