Betaxolol hydrochloride, beta1 adrenoceptor blocker (ab143299)

Overview

  • Product name

    Betaxolol hydrochloride, beta1 adrenoceptor blocker
  • Description

    Selective β1 adrenoceptor blocker
  • Biological description

    Selective β1 adrenoceptor blocker (IC50 = 6 μM). Induces apoptosis in endothelial cells. Shows antihypertensive effects and reduces intraocular pressure in vivo.
  • CAS Number

    63659-19-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol hydrochloride
  • Molecular weight

    343.89
  • Molecular formula

    C18H29NO3.HCl
  • PubChem identifier

    107952
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC(=CC=C1CCOCC2CC2)OCC(CNC(C)C)O).Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Miao Y  et al. Cytotoxic effects of betaxolol on healthy corneal endothelial cells both in vitro and in vivo. Int J Ophthalmol 7:14-21 (2014). Read more (PubMed: 24634857) »
  • Gnus J  et al. Nonspecific effects of ligands on the beta-adrenergic receptors in rabbit abdominal aorta in vitro. Folia Biol (Krakow) 61:263-9 (2013). Read more (PubMed: 24279178) »
  • Wright JM  et al. a- and ß-Adrenergic receptors differentially modulate the emission of spontaneous and amphetamine-induced 50-kHz ultrasonic vocalizations in adult rats. Neuropsychopharmacology 37:808-21 (2012). Read more (PubMed: 22030713) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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