Overview

  • Product name

    Biapenem, antibiotic agent
  • Description

    Highly broad spectrum antibiotic agent
  • Biological description

    Highly broad spectrum antibiotic agent. Stable against dehydropeptidase I. Shows bactericidal effects against Gram-negative and Gram-positive aerobic and anaerobic bacteria, including β-lactamase producing species in vivo.
  • Purity

    > 99%
  • CAS Number

    120410-24-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4R,5S,6S)-3-(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • Molecular weight

    350.39
  • Molecular formula

    C15H18N4O4S
  • PubChem identifier

    71339
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1([C@@]([C@@]2(N1C(=C([C@@H]2C)SC3CN4[N+](C3)=CC=N4)C(=O)[O-])[H])(C(C)O)[H])=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Goldstein EJ  et al. In vitro activity of Biapenem plus RPX7009, a carbapenem combined with a serine ß-lactamase inhibitor, against anaerobic bacteria. Antimicrob Agents Chemother 57:2620-30 (2013). Read more (PubMed: 23529731) »
  • Yamada K  et al. In vivo efficacy of biapenem with ME1071, a novel metallo-ß-lactamase (MBL) inhibitor, in a murine model mimicking ventilator-associated pneumonia caused by MBL-producing Pseudomonas aeruginosa. Int J Antimicrob Agents 42:238-43 (2013). Read more (PubMed: 23891525) »
  • Yamada K  et al. In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa. J Infect Chemother 18:472-8 (2012). Read more (PubMed: 22215228) »

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