Overview

  • Product name

  • Description

    Rabbit polyclonal to BICD2
  • Host species

    Rabbit
  • Specificity

    this antibody does not cross react with BICD1.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a 13 amino acid peptide from near the carboxy terminus of human BICD2.

  • Positive control

    • A549 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab73286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 93 kDa (predicted molecular weight: 93 kDa).

Target

  • Function

    May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Belongs to the BicD family.
  • Domain

    The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2.
  • Post-translational
    modifications

    Phosphorylated by NEK9 in vitro.
  • Cellular localization

    Golgi apparatus. Cytoplasm > cytoskeleton. In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Its localization is dependent on microtubule morphology.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA526D8.1 antibody
    • Bic D 2 antibody
    • Bic-D 2 antibody
    • Bicaudal D homolog 2 (Drosophila) antibody
    • Bicaudal D homolog 2 antibody
    • Bicd2 antibody
    • BICD2_HUMAN antibody
    • Coiled coil protein BICD2 antibody
    • Cytoskeleton like bicaudal D protein homolog 2 antibody
    • Homolog of Drosophila bicaudal D antibody
    • KIAA0699 antibody
    • Protein bicaudal D homolog 2 antibody
    see all

Images

  • Lane 1 : Anti-BICD2 antibody (ab73286) at 1 µg/ml
    Lane 2 : Anti-BICD2 antibody (ab73286) at 2 µg/ml

    All lanes : A549 cell lysate

    Lysates/proteins at 15 µg/ml per lane.

    Predicted band size: 93 kDa
    Observed band size: 93 kDa

References

This product has been referenced in:

  • Turgay Y  et al. SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown. J Cell Biol 204:1099-109 (2014). Read more (PubMed: 24662567) »
See 1 Publication for this product

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