Overview

  • Product name

  • Description

    Rabbit polyclonal to BIG-2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human BIG-2 aa 777-1026.
    Sequence:

    VGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL EKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLA VKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKA LDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFS DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL


    Database link: Q8IWV2-1

  • Positive control

    • IHC-P: Human brain and skin tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab229927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
  • Tissue specificity

    Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.
  • Involvement in disease

    A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization

    Cell membrane. Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AXCAM antibody
    • Axonal associated cell adhesion molecule antibody
    • BIG 2 antibody
    • BIG-2 antibody
    • Brain derived immunoglobulin superfamily protein 2 antibody
    • Brain-derived immunoglobulin superfamily protein 2 antibody
    • Cntn4 antibody
    • CNTN4_HUMAN antibody
    • CNTN4A antibody
    • contactin 4 antibody
    • Contactin-4 antibody
    • Neural cell adhesion protein BIG 2 antibody
    • SCA16 antibody
    see all

Images

  • Paraffin-embedded human skin tissue stained for BIG-2 with ab229927 at a 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human brain tissue stained for BIG-2 with ab229927 at a 1/100 dilution in immunohistochemical analysis.

References

ab229927 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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