Overview

  • Product name

    Anti-BIG-2 antibody [EPR8735]
    See all BIG-2 primary antibodies
  • Description

    Rabbit monoclonal [EPR8735] to BIG-2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human BIG-2 aa 1-100 (N terminal). The exact sequence is proprietary.

  • Positive control

    • Human fetal brain, Human cerebellum and Mouse brain lysates; Human brain and kidney tissues.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab137107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 113 kDa.
IHC-P 1/50 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IP.
  • Target

    • Function

      Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
    • Tissue specificity

      Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.
    • Involvement in disease

      A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
    • Sequence similarities

      Belongs to the immunoglobulin superfamily. Contactin family.
      Contains 4 fibronectin type-III domains.
      Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
    • Cellular localization

      Cell membrane. Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • AXCAM antibody
      • Axonal associated cell adhesion molecule antibody
      • BIG 2 antibody
      • BIG-2 antibody
      • Brain derived immunoglobulin superfamily protein 2 antibody
      • Brain-derived immunoglobulin superfamily protein 2 antibody
      • Cntn4 antibody
      • CNTN4_HUMAN antibody
      • CNTN4A antibody
      • contactin 4 antibody
      • Contactin-4 antibody
      • Neural cell adhesion protein BIG 2 antibody
      • SCA16 antibody
      see all

    Images

    • All lanes : Anti-BIG-2 antibody [EPR8735] (ab137107) at 1/1000 dilution

      Lane 1 : Human fetal brain lysate
      Lane 2 : Human cerebellum lysate
      Lane 3 : Mouse brain lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP-labelled Goat anti-Rabbit at 1/2000 dilution

      Predicted band size: 113 kDa

    • Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling BIG-2 with ab137107 at 1/50 dilution.

    • Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling BIG-2 with ab137107 at 1/50 dilution.

    References

    ab137107 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab137107.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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