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    biii-antibody-ab223758.pdf

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Signal Transduction Signaling Pathway Calcium Signaling Calcium Channels
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Anti-BIII antibody (ab223758)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BIII antibody (ab223758)

    Key features and details

    • Rabbit polyclonal to BIII
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-BIII antibody
      See all BIII primary antibodies
    • Description

      Rabbit polyclonal to BIII
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Rabbit
    • Immunogen

      Recombinant fragment corresponding to Human BIII aa 1857-1950.
      Sequence:

      ALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR GARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHE


      Database link: Q00975
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • IHC-P: Human cerebral cortex tissue.
    • General notes

      Previously labelled as CACNA1B (N type).

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.20
      Preservative: 0.02% Sodium azide
      Constituents: 40% Glycerol (glycerin, glycerine), PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • Calcium Signaling
      • Calcium Channels

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    Our Abpromise guarantee covers the use of ab223758 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Relevance

      Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
    • Cellular localization

      Membrane; Multi-pass membrane protein.
    • Database links

      • Entrez Gene: 774 Human
      • Entrez Gene: 12287 Mouse
      • Entrez Gene: 100008979 Rabbit
      • Entrez Gene: 257648 Rat
      • Omim: 601012 Human
      • SwissProt: Q00975 Human
      • SwissProt: O55017 Mouse
      • SwissProt: Q05152 Rabbit
      • SwissProt: Q02294 Rat
      see all
    • Alternative names

      • BIII antibody
      • Brain calcium channel III antibody
      • CACH5 antibody
      • CACNA1B (N type) antibody
      • CACNL1A5 antibody
      • CACNN antibody
      • Calcium channel alpha12.2 subunit antibody
      • Calcium channel L type alpha 1 polypeptide isoform 5 antibody
      • Calcium channel L type, alpha 1 polypeptide antibody
      • Calcium channel N type antibody
      • Calcium channel voltage dependent alpha 1B subunit N type antibody
      • Calcium channel voltage dependent L type alpha 1B subunit antibody
      • Calcium channel voltage dependent N type alpha 1B subunit antibody
      • Cav2.2 antibody
      • Cav2.2 voltage gated Ca2+ channel antibody
      • Voltage dependent N type calcium channel subunit alpha 1B antibody
      • Voltage gated calcium channel alpha subunit Cav2.2 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BIII antibody (ab223758)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BIII antibody (ab223758)

      Paraffin embedded sections of human cerebral cortex stained for BIII with ab223758 at 1/50 dilution in immunohistochemical analysis.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab223758? Please let us know so that we can cite the reference in this datasheet.

    ab223758 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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