Overview

  • Product name

    Anti-Bile Acid Receptor NR1H4 antibody
    See all Bile Acid Receptor NR1H4 primary antibodies
  • Description

    Rabbit polyclonal to Bile Acid Receptor NR1H4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Pig
  • Immunogen

    Recombinant fragment within Human Bile Acid Receptor NR1H4 (internal sequence). The exact sequence is proprietary.
    Database link: Q96RI1

  • Positive control

    • WB: HEK-293T, A431, HeLa and HepG2 whole cell extracts; A549, NCI-H1299, HCT 116 and MCF7 whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab228949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 56 kDa.

Target

  • Function

    Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • BAR antibody
    • Bile acid receptor antibody
    • Farnesoid X activated receptor antibody
    • Farnesoid X receptor antibody
    • Farnesoid X-activated receptor antibody
    • Farnesol receptor HRR 1 antibody
    • Farnesol receptor HRR-1 antibody
    • Farnesol receptor HRR1 antibody
    • FXR antibody
    • HRR 1 antibody
    • HRR1 antibody
    • NR1H4 antibody
    • NR1H4_HUMAN antibody
    • Nuclear receptor subfamily 1 group H member 4 antibody
    • Retinoid X receptor interacting protein 14 antibody
    • Retinoid X receptor-interacting protein 14 antibody
    • RIP 14 antibody
    • RIP14 antibody
    • RXR interacting protein 14 antibody
    • RXR-interacting protein 14 antibody
    see all

Images

  • All lanes : Anti-Bile Acid Receptor NR1H4 antibody (ab228949) at 1/500 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract
    Lane 2 : A431 (human epidermoid carcinoma cell line) whole cell extract
    Lane 3 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract
    Lane 4 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract

    Lysates/proteins at 30 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 56 kDa



    10% SDS-PAGE

  • All lanes : Anti-Bile Acid Receptor NR1H4 antibody (ab228949) at 1/1000 dilution

    Lane 1 : A549 (human lung carcinoma cell line) whole cell lysate
    Lane 2 : NCI-H1299 (human lung carcinoma cell line) whole cell lysate
    Lane 3 : HCT 116 (human colorectal carcinoma cell line) whole cell lysate
    Lane 4 : MCF7 (human breast adenocarcinoma cell line) whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 56 kDa



    10% SDS-PAGE

References

ab228949 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228949.
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