Description

Specifications

Our Abpromise guarantee covers the use of ab209973 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab126602

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • BAR
    • Bile acid receptor
    • Farnesoid X activated receptor
    • Farnesoid X receptor
    • Farnesoid X-activated receptor
    • Farnesol receptor HRR 1
    • Farnesol receptor HRR-1
    • Farnesol receptor HRR1
    • FXR
    • HRR 1
    • HRR1
    • NR1H4
    • NR1H4_HUMAN
    • Nuclear receptor subfamily 1 group H member 4
    • Retinoid X receptor interacting protein 14
    • Retinoid X receptor-interacting protein 14
    • RIP 14
    • RIP14
    • RXR interacting protein 14
    • RXR-interacting protein 14
    see all
  • Function

    Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab209973 has not yet been referenced specifically in any publications.

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