• Product name

    Anti-Bile salt-activated lipase antibody
    See all Bile salt-activated lipase primary antibodies
  • Description

    Rabbit polyclonal to Bile salt-activated lipase
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Non human primates
  • Immunogen

    Synthetic peptide corresponding to Bile salt-activated lipase aa 700 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab86686)

  • Positive control

    • This antibody gave a positive signal in the following tissue lysates: Mouse Pancreas; Human Pancreas



Our Abpromise guarantee covers the use of ab79131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 78 kDa).


  • Relevance

    Defects in Bile salt activated lipase (CEL) are a cause of maturity onset diabetes of the young type 8 with exocrine dysfunction (MODY8) [MIM:609812], also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY [MIM:606391] is an autosomal dominant form of diabetes mellitus. The pancreas serves both endocrine and exocrine functions. The endocrine cells are found in the islets of Langerhans. They synthesize insulin and other hormones, and are involved in the pathogenesis of diabetes mellitus. The exocrine cells produce bicarbonate and digestive enzymes and are involved in the pathogenesis of pancreatic malabsorption. The localization of the islets within exocrine pancreatic tissue is suggestive of an interdependency and cross talk between these two cell populations in their normal and in their abnormal function.
  • Cellular localization

    Cytoplasmic and Nuclear
  • Database links

  • Alternative names

    • BAL antibody
    • Bile salt-stimulated lipase antibody
    • BSDL antibody
    • BSSL antibody
    • Bucelipase antibody
    • Carboxyl ester lipase (bile salt stimulated lipase) antibody
    • Carboxyl ester lipase antibody
    • CEase antibody
    • CEL antibody
    • CELL antibody
    • Cholesterol esterase antibody
    • FAP antibody
    • FAPP antibody
    • Fetoacinar pancreatic protein antibody
    • LIPA antibody
    • Lysophospholipase, pancreatic antibody
    • MODY8 antibody
    • Pancreatic lysophospholipase antibody
    • Sterol esterase antibody
    see all


  • All lanes : Anti-Bile salt-activated lipase antibody (ab79131) at 1 µg/ml

    Lane 1 : Human pancreas tissue lysate - total protein (ab29816)
    Lane 2 : Pancreas (Mouse) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 78 kDa
    Observed band size: 74 kDa
    why is the actual band size different from the predicted?

    We hypothesize that the 74 kDa band represents the mature form of Bile salt-activated lipase, which has had its signal sequenced cleaved off.
  • IHC image of Bile salt-activated lipase staining in mouse pancreas formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab79131, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.


This product has been referenced in:

  • Wolters-Eisfeld G  et al. Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice. Exp Mol Med 50:133 (2018). Read more (PubMed: 30305605) »
See 1 Publication for this product

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