Overview

  • Product name

    Bindarit, CCL2, CCL7 and CCL8 inhibitor
  • Description

    CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent.
  • Biological description

    CCL2, CCL7 and CCL8 inhibitor. Anti-inflammatory agent. Shows antiproliferative, antimetastatic and antitumor effects in vivo. Prevents neuroinflammation in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    130641-38-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid
  • Molecular weight

    324.38
  • Molecular formula

    C19H20N2O3
  • PubChem identifier

    71354
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)C(C)(C)OCc3nn(Cc1ccccc1)c2ccccc23
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Steiner JL  et al. Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer. Cytokine 66:60-8 (2014). Read more (PubMed: 24548426) »
  • Ge S  et al. The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis. J Neuroinflammation 9:171 (2012). Read more (PubMed: 22788993) »
  • Zoja C  et al. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int 53:726-34 (1998). Read more (PubMed: 9507220) »
See 1 Publication for this product

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