Overview

  • Product name

    BIO-acetoxime, GSK-3alpha/beta inhibitor
  • Description

    Potent and selective GSK-3α/β inhibitor
  • Biological description

    Potent and selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling. Inhibits CD8+ T cell differentiation. Shows antiapoptotic effects.
  • Purity

    > 98%
  • CAS Number

    667463-85-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one
  • Molecular weight

    398.22
  • Molecular formula

    C18H12BrN3O3
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)O\N=C3/c4ccccc4N/C3=C1/c2ccc(Br)cc2NC1=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wang B  et al. Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44? gastric cancer cells via attenuating Wnt signaling. J Gastroenterol 48:798-808 (2013). Read more (PubMed: 23188090) »
  • Hsu MJ & Hung SL Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol 158:1287-96 (2013). Read more (PubMed: 23392633) »
  • Spokoini R  et al. Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol Endocrinol 24:1136-50 (2010). Read more (PubMed: 20371704) »

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