Biotin Anti-Antithrombin III/ATIII antibody (ab79933)
Key features and details
- Biotin Rabbit polyclonal to Antithrombin III/ATIII
- Reacts with: Mouse
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-Antithrombin III/ATIII antibody
See all Antithrombin III/ATIII primary antibodies -
Description
Biotin Rabbit polyclonal to Antithrombin III/ATIII -
Host species
Rabbit -
Conjugation
Biotin -
Species reactivity
Reacts with: Mouse -
Immunogen
Full length native protein (purified) corresponding to Mouse Antithrombin III/ATIII.
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General notes
Previously labelled as Antithrombin III.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.25% BSA -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
RIA: Use at a concentration of 4 µg/ml.
WB: Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. -
Tissue specificity
Found in plasma. -
Involvement in disease
Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. -
Sequence similarities
Belongs to the serpin family. -
Post-translational
modificationsPhosphorylation sites are present in the extracelllular medium. -
Cellular localization
Secreted > extracellular space. - Information by UniProt
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Database links
- Entrez Gene: 11905 Mouse
- SwissProt: P32261 Mouse
- Unigene: 260770 Mouse
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Alternative names
- ANT3_HUMAN antibody
- Antithrombin antibody
- Antithrombin III antibody
see all
References (1)
ab79933 has been referenced in 1 publication.
- Hansen CB et al. The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema. J Immunol 195:3596-604 (2015). PubMed: 26371246
