Biotin Anti-Apolipoprotein CII/ApoC-II antibody (ab27633)
Key features and details
- Biotin Goat polyclonal to Apolipoprotein CII/ApoC-II
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-Apolipoprotein CII/ApoC-II antibody
See all Apolipoprotein CII/ApoC-II primary antibodies -
Description
Biotin Goat polyclonal to Apolipoprotein CII/ApoC-II -
Host species
Goat -
Conjugation
Biotin -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human Apolipoprotein CII/ApoC-II.
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General notes
This product was previously labelled as Apolipoprotein CII
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 0.2% PBS, 0.435% Sodium chloride -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
This antibody was purified by human Apolipoprotein CII/ApoC-II-Sepharose. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Target
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Function
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. -
Tissue specificity
Liver and intestine. -
Involvement in disease
Hyperlipoproteinemia 1B -
Sequence similarities
Belongs to the apolipoprotein C2 family. -
Post-translational
modificationsProapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 344 Human
- Omim: 608083 Human
- SwissProt: P02655 Human
- Unigene: 75615 Human
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Alternative names
- APC 2 antibody
- APC2 antibody
- Apo CII antibody
see all
Datasheets and documents
References (1)
ab27633 has been referenced in 1 publication.
- Dernick G et al. Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays. J Lipid Res 52:2323-31 (2011). PubMed: 21971713