Biotin Anti-Apolipoprotein CII/ApoC-II antibody (ab27633)

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Key features and details

  • Biotin Goat polyclonal to Apolipoprotein CII/ApoC-II
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

Overview

  • Product name

    Biotin Anti-Apolipoprotein CII/ApoC-II antibody
    See all Apolipoprotein CII/ApoC-II primary antibodies

  • Description

    Biotin Goat polyclonal to Apolipoprotein CII/ApoC-II

  • Host species

    Goat

  • Conjugation

    Biotin

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant full length protein corresponding to Human Apolipoprotein CII/ApoC-II.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Target

  • Function

    Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

  • Tissue specificity

    Liver and intestine.

  • Involvement in disease

    Hyperlipoproteinemia 1B

  • Sequence similarities

    Belongs to the apolipoprotein C2 family.

  • Post-translational
    modifications

    Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
    Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • APC 2 antibody
      • APC2 antibody
      • Apo CII antibody
      • Apo-CII antibody
      • APOC 2 antibody
      • ApoC II antibody
      • ApoC-II antibody
      • APOC2 antibody
      • APOC2 protein antibody
      • APOC2_HUMAN antibody
      • ApoCII antibody
      • Apolipoprotein C II antibody
      • Apolipoprotein C II precursor antibody
      • Apolipoprotein C2 antibody
      • ApolipoproteinCII antibody
      • MGC75082 antibody
      • ProapoC-II antibody
      • Proapolipoprotein C-II antibody
      see all

    References (1)

    Publishing research using ab27633? Please let us know so that we can cite the reference in this datasheet.

    ab27633 has been referenced in 1 publication.

    • Dernick G  et al. Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays. J Lipid Res 52:2323-31 (2011). PubMed: 21971713

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