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  1. Link

    biotin-c5b-9--c5b-8-antibody-ae11-ab237699.pdf

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Immunology Innate Immunity Complement Classical Pathway
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Biotin Anti-C5b-9 + C5b-8 antibody [aE11] (ab237699)

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Key features and details

  • Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8
  • Suitable for: ELISA
  • Reacts with: Horse, Human, Pig, Baboon
  • Conjugation: Biotin
  • Isotype: IgG2a

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Overview

  • Product name

    Biotin Anti-C5b-9 + C5b-8 antibody [aE11]
  • Description

    Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Specificity

    ab237699 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive).

    The aE11 monoclonal was first reported to bind to a neoepitope exposed on polymerized C9 when incorporated into the human terminal complement complex (PubMed ID: 4035298). It was subsequently shown that this antibody also cross reacts with the C5b-8 complex and purified C8 alpha-gamma. It does not react with native C9 or C8 proteins (PubMed ID: 2424021).

  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Horse, Human, Pig, Baboon
  • Immunogen

    Full length native protein (purified) corresponding to Human C5b-9.
    Database link: P01031

  • Epitope

    ab237699 binds to a neoepitope exposed on C9.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.0975% Sodium azide
    Constituents: 0.16% Sodium phosphate, 0.81% Sodium chloride
  • Concentration information loading...
  • Purity

    Affinity purified
  • Purification notes

    Biotinylated
  • Clonality

    Monoclonal
  • Clone number

    aE11
  • Isotype

    IgG2a
  • Light chain type

    kappa
  • Research areas

    • Immunology
    • Innate Immunity
    • Complement
    • Classical Pathway
    • Immunology
    • Innate Immunity
    • Complement
    • Alternative Pathway
    • Immunology
    • Innate Immunity
    • Complement
    • Regulatory

Associated products

  • Alternative Versions

    • Anti-C5b-9 + C5b-8 antibody [aE11] (ab66768)
  • Isotype control

    • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab237699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Use at an assay dependent concentration.
Notes
ELISA
Use at an assay dependent concentration.

Target

  • Cellular localization

    C5b-9: Secreted
  • Database links

    • Entrez Gene: 727 Human
    • Entrez Gene: 729 Human
    • Entrez Gene: 730 Human
    • Entrez Gene: 731 Human
    • Entrez Gene: 735 Human
    • SwissProt: P01031 Human
    • SwissProt: P02748 Human
    • SwissProt: P07357 Human
    • SwissProt: P10643 Human
    • SwissProt: P13671 Human
    see all

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab237699? Please let us know so that we can cite the reference in this datasheet.

ab237699 has not yet been referenced specifically in any publications.

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