Biotin Anti-C5b-9 + C5b-8 antibody [aE11] (ab237699)

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Key features and details

  • Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8
  • Reacts with: Horse, Human, Pig, Baboon
  • Conjugation: Biotin
  • Isotype: IgG2a

Overview

  • Product name

    Biotin Anti-C5b-9 + C5b-8 antibody [aE11]

  • Description

    Biotin Mouse monoclonal [aE11] to C5b-9 + C5b-8

  • Host species

    Mouse

  • Conjugation

    Biotin

  • Specificity

    ab237699 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive).

    The aE11 monoclonal was first reported to bind to a neoepitope exposed on polymerized C9 when incorporated into the human terminal complement complex (PubMed ID: 4035298). It was subsequently shown that this antibody also cross reacts with the C5b-8 complex and purified C8 alpha-gamma. It does not react with native C9 or C8 proteins (PubMed ID: 2424021).

  • Species reactivity

    Reacts with: Horse, Human, Pig, Baboon

  • Immunogen

    Full length native protein (purified) corresponding to Human C5b-9.
    Database link: P01031

  • Epitope

    ab237699 binds to a neoepitope exposed on C9.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Target

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab237699? Please let us know so that we can cite the reference in this datasheet.

ab237699 has not yet been referenced specifically in any publications.

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