Key features and details
- Biotin Mouse monoclonal [ICRF44] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
Product nameBiotin Anti-CD11b antibody [ICRF44]
See all CD11b primary antibodies
DescriptionBiotin Mouse monoclonal [ICRF44] to CD11b
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Human
Predicted to work with: Non human primates
Tissue, cells or virus corresponding to Human CD11b. Rheumatoid synovial cells and human monocytes.
- Flow: Human peripheral blood.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
Storage bufferpH: 7.40
Preservative: 0.0975% Sodium azide
Concentration information loading...
Purification notesThe purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
- PE/Cy7® Anti-CD11b antibody [ICRF44], prediluted (ab135929)
- FITC Anti-CD11b antibody [ICRF44] (ab176541)
- Alexa Fluor® 488 Anti-CD11b antibody [ICRF44], prediluted (ab187597)
- APC/Cy7® Anti-CD11b antibody [ICRF44] (ab197129)
- APC Anti-CD11b antibody [ICRF44] (ab218639)
- FITC Anti-CD11b antibody [ICRF44] (ab269333)
- PE Anti-CD11b antibody [ICRF44] (ab269334)
- Anti-CD11b antibody [ICRF44] (ab34216)
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab239235 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 12 µg/ml.
Use a concentration of 1 - 12 µg/ml.
FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue specificityPredominantly expressed in monocytes and granulocytes.
Involvement in diseaseGenetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Information by UniProt
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab239235 has not yet been referenced specifically in any publications.