Biotin Anti-CD38 antibody [90] (ab25004)

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Key features and details

  • Biotin Rat monoclonal [90] to CD38
  • Conjugation: Biotin
  • Isotype: IgG2a

Overview

  • Product name

    Biotin Anti-CD38 antibody [90]
    See all CD38 primary antibodies

  • Description

    Biotin Rat monoclonal [90] to CD38

  • Host species

    Rat

  • Conjugation

    Biotin

  • Immunogen

    Tissue, cells or virus corresponding to CD38. Mouse bone marrow pre-B cells

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Target

  • Function

    Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

  • Tissue specificity

    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

  • Sequence similarities

    Belongs to the ADP-ribosyl cyclase family.

  • Developmental stage

    Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Form

    There are 2 isoforms produced by alternative splicing.

  • Alternative names

    • Acute lymphoblastic leukemia cells antigen CD38 antibody
    • ADP ribosyl cyclase 1 antibody
    • ADP ribosyl cyclase antibody
    • ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody
    • ADP-ribosyl cyclase 1 antibody
    • ADPRC 1 antibody
    • ADPRC1 antibody
    • cADPr hydrolase 1 antibody
    • CD 38 antibody
    • CD38 antibody
    • CD38 antigen (p45) antibody
    • CD38 antigen antibody
    • CD38 molecule antibody
    • Cd38-rs1 antibody
    • CD38_HUMAN antibody
    • CD38H antibody
    • Cyclic ADP ribose hydrolase antibody
    • Cyclic ADP ribose hydrolase 1 antibody
    • Cyclic ADP-ribose hydrolase 1 antibody
    • EC 3.2.2.5 antibody
    • Ecto nicotinamide adenine dinucleotide glycohydrolase antibody
    • I-19 antibody
    • I19 (mouse) antibody
    • Lymphocyte differentiation antigen CD38 antibody
    • NAD(+) nucleosidase antibody
    • NIM-R5 antigen antibody
    • NIMR5 antigen (mouse) antibody
    • OTTHUMP00000158633 antibody
    • OTTHUMP00000217743 antibody
    • p45 antibody
    • T10 antibody
    see all

References (0)

Publishing research using ab25004? Please let us know so that we can cite the reference in this datasheet.

ab25004 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

Can you please show me the IHC image?

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Answer

Thank you for your enquiry.

This product, clone 90, is a licensed clone and information regarding the IHC application was described in the original article listed below.


Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. Journal of Immunology 1997; 158(3):1108-15

http://www.ncbi.nlm.nih.gov/pubmed/9013949

I am afraid that we do not have access to the journal from our side but most probably your university library will have subscription to the journal.

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