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    biotin-cd41-antibody-mem-06-ab28065.pdf

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Cardiovascular Angiogenesis Adhesion / ECM Integrins
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Biotin Anti-CD41 antibody [MEM-06] (ab28065)

  • Datasheet
  • SDS
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Key features and details

  • Biotin Mouse monoclonal [MEM-06] to CD41
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG1

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Overview

  • Product name

    Biotin Anti-CD41 antibody [MEM-06]
    See all CD41 primary antibodies
  • Description

    Biotin Mouse monoclonal [MEM-06] to CD41
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Specificity

    ab28065 recognises CD41/integrin alpha 2b
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human CD41. Tissue/ cell preparation (Human): Leucocytes of patient suffering from LGL-type leukaemia.
    Database link: P08514

  • General notes

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Clonality

    Monoclonal
  • Clone number

    MEM-06
  • Isotype

    IgG1
  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Adhesion / ECM
    • Integrins
    • Cardiovascular
    • Blood
    • Platelets
    • Immunology
    • Cell Type Markers
    • CD
    • Platelets
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Integrins
    • Alpha
    • Stem Cells
    • Hematopoietic Progenitors
    • Hematopoietic Stem Cells
    • Murine Lineage Negative
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Thrombocytic Lineage

Associated products

  • Alternative Versions

    • PE Anti-CD41 antibody [MEM-06], prediluted (ab134372)
    • PerCP Anti-CD41 antibody [MEM-06], prediluted (ab134373)
    • FITC Anti-CD41 antibody [MEM-06] (ab21851)
    • Anti-CD41 antibody [MEM-06] (ab2211)
    • PE/Cy5® Anti-CD41 antibody [MEM-06] (ab233450)
    • PE/Cy7® Anti-CD41 antibody [MEM-06] (ab239313)
    • Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
    • APC Anti-CD41 antibody [MEM-06] (ab55866)
  • Isotype control

    • Biotin Mouse IgG1, Kappa Monoclonal [MOPC-21] - isotype control (ab18434)

Target

  • Function

    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
  • Tissue specificity

    Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
  • Involvement in disease

    Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
  • Sequence similarities

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P08514 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3674 Human
    • Omim: 607759 Human
    • SwissProt: P08514 Human
    • Unigene: 411312 Human
    • Alternative names

      • antigen CD41 antibody
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD41 antibody
      • CD41B antibody
      • form 2 antibody
      • GP2B antibody
      • GPalpha IIb antibody
      • GPIIb antibody
      • GT antibody
      • GTA antibody
      • HPA3 antibody
      • Integrin alpha 2b antibody
      • Integrin alpha IIb antibody
      • Integrin alpha-IIb light chain antibody
      • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
      • ITA2B_HUMAN antibody
      • Itga2b antibody
      • ITGAB antibody
      • platelet fibrinogen receptor, alpha subunit antibody
      • platelet glycoprotein IIb of IIb/IIIa complex antibody
      • Platelet membrane glycoprotein IIb antibody
      • platelet specific antigen BAK antibody
      • PPP1R93 antibody
      see all

    Protocols

    • Flow cytometry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab28065? Please let us know so that we can cite the reference in this datasheet.

    ab28065 has been referenced in 1 publication.

    • LeMaoult J  et al. HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells. Proc Natl Acad Sci U S A 101:7064-9 (2004). PubMed: 15103024

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