Overview

  • Product name

    Biotin-DEVD-FMK, caspase-3 inhibitor
  • Description

    Biotin-conjugated, potent, irreversible caspase-3 inhibitor. Cell-permeable.
  • Biological description

    Biotin-conjugated, potent, irreversible caspase-3 inhibitor (IC50 = 35.8 nM). Inhibits apoptosis in multiple biological systems. Neuroprotective and active in vivo. Biotin-conjugation allows detection of activated caspases in conjunction with avidin-tags. Cell-permeable.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mintzer R  et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One 7:e30376 (2012). Read more (PubMed: 22253931) »
  • Kondratyev A & Gale K Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus. Brain Res Mol Brain Res 75:216-24 (2000). Read more (PubMed: 10686342) »
  • Henshall DC  et al. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J Neurochem 74:1215-23 (2000). Read more (PubMed: 10693954) »

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