Biotin Anti-Factor V antibody (ab48230)

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Key features and details

  • Biotin Rabbit polyclonal to Factor V
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

Overview

  • Product name

    Biotin Anti-Factor V antibody
    See all Factor V primary antibodies

  • Description

    Biotin Rabbit polyclonal to Factor V

  • Host species

    Rabbit

  • Conjugation

    Biotin

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Full length native Factor V purified from plasma (Human).

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Storage buffer

    pH: 7.50
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...

  • Purity

    Protein G purified

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Research areas

Associated products

Target

  • Function

    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

  • Tissue specificity

    Plasma.

  • Involvement in disease

    Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1

  • Sequence similarities

    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.

  • Domain

    Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.

  • Post-translational
    modifications

    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    References (0)

    Publishing research using ab48230? Please let us know so that we can cite the reference in this datasheet.

    ab48230 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Question

    I have a few questions on the anti-FV antibodies you offer:
    -anti-FV antibody (Biotin) ab48230: has it been tested whether thisantibody recognizes activated FV (FVa) and/or activated FV products?
    Also, is it known whether this antibody cross reacts with species other than human FV?
    -anti-FV antibody ab61368: has it been tested whether this antibodyrecognizes activated bovine FV (FVa) and/or activated bovine FV products? Also, is it known whether this antibody cross reacts with species other than bovine FV?
    -anti-FV antibody ab21037:is it known whether this antibody cross reacts with species other than human FV?
    I'm looking for an antiFV antibody that is highly cross reactive and nonspecific, hence my questions.
    Many thanks,

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    Answer

    First of all I would like to apologise for the delay in getting back to you.I really appreciate your patience and comprehension.

    -In regards to antibody ab21037, I am afraid it has only been tested against human factor V, therefore it is unknown whether it could cross react with other species.

    - Product ab61368 is a polyclonal antibody and it may bind to multiple epitopes, recognising the activated protein as well. The only other species we have tested against for cross reactivity is human and it cross reacts very weakly.

    -Regarding ab48230, this antibody can recognize FVa and it has not been tested against other species yet.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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