Key features and details
- Biotin Goat polyclonal to Folate Binding Protein/FBP
- Reacts with: Cow
- Conjugation: Biotin
- Isotype: IgG
Product nameBiotin Anti-Folate Binding Protein/FBP antibody
See all Folate Binding Protein/FBP primary antibodies
DescriptionBiotin Goat polyclonal to Folate Binding Protein/FBP
Species reactivityReacts with: Cow
Full length protein corresponding to Cow Folate Binding Protein/FBP.
10-20 Biotin molecules per goat IgG molecule.
Previously labelled as Folate Binding Protein
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 1% BSA, 0.42% Potassium phosphate, 0.87% Sodium chloride
BSA is IgG and Protease free
Concentration information loading...
Purification notesThis product is purified by a multi-step process including delipidation, salt fractionation, ion exchange chromatography and extensive dialysis against buffer.
ELISA: 1/4000 - 1/20000.
This product has been assayed against 1.0µg of Folate Binding Protein in a standard capture ELISA using Peroxidase conjugated streptavidin and ABTS (2,2'-azino-bis-[3-ethylbenthiazoline-6-sulfonic-acid]) as a substrate for 30 minutes at RT.
IM: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Suitable for other antibody based assays using streptavidin or avidin conjugates.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionBinds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
Tissue specificityExclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
Involvement in diseaseDefects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
Sequence similaritiesBelongs to the folate receptor family.
modificationsEight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Cellular localizationCell membrane. Secreted.
- Information by UniProt
- adult antibody
- Adult folate binding protein antibody
- Adult folate-binding protein antibody
ab34529 has not yet been referenced specifically in any publications.