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  1. Link

    biotin-hepatitis-c-virus-core-antigen-antibody-h6-29-ab192050.pdf

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Microbiology Organism Virus RNA Virus ssRNA positive strand virus HCV
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Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)

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Western blot - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
  • Immunocytochemistry/ Immunofluorescence - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
  • Immunohistochemistry (Frozen sections) - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)

Key features and details

  • Biotin Mouse monoclonal [H6-29] to Hepatitis C Virus Core Antigen
  • Suitable for: ICC/IF, WB, IHC-Fr
  • Reacts with: Hepatitis C virus
  • Conjugation: Biotin
  • Isotype: IgG2a

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Overview

  • Product name

    Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29]
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description

    Biotin Mouse monoclonal [H6-29] to Hepatitis C Virus Core Antigen
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Frmore details
  • Species reactivity

    Reacts with: Hepatitis C virus
  • Immunogen

    Recombinant fragment within Hepatitis C virus Hepatitis C Virus Core Antigen aa 1-150 (internal sequence). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. corresponding to part of the Core protein region. Expressed in E. coli.
    Database link: P26663

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Chimpanzee liver infected with recombinant vaccinia virus containing a Hepatitis C virus genome cDNA lysate and cells. Human liver tissue from a patient with chronic hepatitis C.
  • General notes

    Biotin conjugated [biotin] / [IgG] = 6.6.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
  • Storage buffer

    pH: 6
    Constituents: 50% PBS, 50% Glycerol (glycerin, glycerine)

    Filter-sterilized.
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    H6-29
  • Isotype

    IgG2a
  • Light chain type

    kappa
  • Research areas

    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • HCV
    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • Hepatitis A/C/E/G

Associated products

  • Isotype control

    • Biotin Mouse IgG2a, kappa [MOPC-173] - Isotype Control (ab18454)
  • Related Products

    • Recombinant Hepatitis C Virus NS4A protein (ab84350)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab192050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
IHC-Fr
Use at an assay dependent concentration.
Notes
ICC/IF
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
IHC-Fr
Use at an assay dependent concentration.

Target

  • Relevance

    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localization

    Endoplasmic reticulum
  • Database links

    • SwissProt: P26664 Hepatitis C virus
    • SwissProt: P29846 Hepatitis C virus
    • Alternative names

      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    Images

    • Western blot - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
      Western blot - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
      Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050) + chimpanzee liver infected with recombinant vaccinia virus containing a Hepatitis C virus genome cDNA cell lysate

      Predicted band size: 22 kDa
      Observed band size: 22 kDa

    • Immunocytochemistry/ Immunofluorescence - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
      Immunocytochemistry/ Immunofluorescence - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)

      Immunofluorescence analysis of acetone-fixed cells from chimpanzee liver infected with recombinant vaccinia virus containing a Hepatitis C virus genome cDNA cells, labeling Hepatitis C Virus NS4A using ab192050.

    • Immunohistochemistry (Frozen sections) - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)
      Immunohistochemistry (Frozen sections) - Biotin Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (ab192050)

      Immunohistochemical analysis of Human liver tissue from a patient with chronic hepatitis C, labeling Hepatitis C Virus NS4A using ab192050. Counterstained with hematoxylin.

    Protocols

    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab192050? Please let us know so that we can cite the reference in this datasheet.

    ab192050 has not yet been referenced specifically in any publications.

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