Overview

  • Product name
    Biotin-IETD-FMK, caspase-8 inhibitor
  • Description
    Biotinylated, irreversible caspase-8 inhibitor
  • Biological description
    Biotinylated, irreversible caspase-8 inhibitor. Inhibits propapoptotic effect of TNFα in vitro (IC50 = 39 μM). Promotes neuronal survival and regeneration in vitro. Cell permeable.
  • Purity
    > 95%
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Monnier PP  et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci 31:10494-505 (2011). Read more (PubMed: 21775595) »
  • Cowburn AS  et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood 105:2970-2 (2005). Read more (PubMed: 15572588) »
  • Jones SA  et al. The effect of specific caspase inhibitors on TNF-alpha and butyrate-induced apoptosis of intestinal epithelial cells. Exp Cell Res 292:29-39 (2004). Read more (PubMed: 14720504) »

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