Biotin Anti-IL-2 Receptor alpha antibody [14313] (ab187683)
![Immunohistochemistry (Frozen sections) - Biotin Anti-IL-2 Receptor alpha antibody [14313] (ab187683)](https://www.abcam.com/ps/products/187/ab187683/Images/ab187683-220100-anti-il-2-receptor-alpha-antibody-14313-biotin-immunohistochemistry.jpg "Immunohistochemistry (Frozen sections) - Biotin Anti-IL-2 Receptor alpha antibody [14313] (ab187683)")
Key features and details
- Biotin Mouse monoclonal [14313] to IL-2 Receptor alpha
- Suitable for: IHC-Fr
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
Overview
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Product name
Biotin Anti-IL-2 Receptor alpha antibody [14313]
See all IL-2 Receptor alpha primary antibodies -
Description
Biotin Mouse monoclonal [14313] to IL-2 Receptor alpha -
Host species
Mouse -
Conjugation
Biotin -
Specificity
ab187683 stains less than 5% of resting human peripheral blood mononuclear cells in flow cytometry. -
Tested applications
Suitable for: IHC-Frmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human IL-2 Receptor alpha. Stimulated human leukocytes
Database link: P01589 -
Epitope
ab187683 recognizes epitope region C of the IL-2 receptor complex. -
Positive control
- Human tonsil
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark. -
Storage buffer
pH: 7.20
Preservative: 0.05% KATHON™ CG/ICP
Constituents: 99% PBS, 0.5% BSA -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
14313 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab187683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-Fr | Use a concentration of 10 µg/ml. |
Target
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Function
Receptor for interleukin-2. -
Involvement in disease
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. -
Sequence similarities
Contains 2 Sushi (CCP/SCR) domains. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3559 Human
- Omim: 147730 Human
- SwissProt: P01589 Human
- Unigene: 231367 Human
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Alternative names
- Interleukin 2 receptor alpha chain antibody
- CD25 antibody
- CD25 antigen antibody
see all
Images
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Immunohistochemistry (Frozen sections) - Biotin Anti-IL-2 Receptor alpha antibody [14313] (ab187683)
Immunohistochemical analysis of frozen sections of human tonsil labeling IL-2 Receptor alpha with ab187683 at 10 µg/ml
Protocols
References (0)
ab187683 has not yet been referenced specifically in any publications.
