Biotin Anti-Insulin + Proinsulin antibody [D3E7] (ab20756)
Key features and details
- Biotin Mouse monoclonal [D3E7] to Insulin + Proinsulin
- Reacts with: Mouse, Rat, Cow, Human, Pig
- Conjugation: Biotin
- Isotype: IgG1
Overview
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Product name
Biotin Anti-Insulin + Proinsulin antibody [D3E7]
See all Insulin + Proinsulin primary antibodies -
Description
Biotin Mouse monoclonal [D3E7] to Insulin + Proinsulin -
Host species
Mouse -
Conjugation
Biotin -
Species reactivity
Reacts with: Mouse, Rat, Cow, Human, Pig -
Immunogen
Full length protein corresponding to Human Insulin + Proinsulin.
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Positive control
- IHC-Fr: Human pancreas tissue.
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General notes
For concentration (OD280nm, E0.1% = 1.4). Affinity constant Kd = 6.3 x 10E-8M.Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 0.79% Tris HCl, 0.87% Sodium chloride -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
>90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis. Purified antibody is conjugated to biotin isothiocyanate. Produced in TCS -
Clonality
Monoclonal -
Clone number
D3E7 -
Myeloma
x63-Ag8.653 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Affibody® Molecule
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Alternative Versions
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ELISA pair antibody
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Isotype control
Target
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Relevance
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Defects in insulin are the cause of familial hyperproinsulinemia. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 280829 Cow
- Entrez Gene: 3630 Human
- Entrez Gene: 16333 Mouse
- Entrez Gene: 16334 Mouse
- Entrez Gene: 24505 Rat
- Omim: 176730 Human
- SwissProt: P01317 Cow
- SwissProt: P01308 Human
see all -
Alternative names
- ILPR antibody
- ins antibody
- Insulin antibody
see all
References (2)
ab20756 has been referenced in 2 publications.
- Kuhn C et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med 3:68ra10 (2011). IHC-Fr ; Mouse . PubMed: 21289272
- Yang RY et al. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A 108:18696-701 (2011). ELISA ; Mouse . PubMed: 21969596