Biotin Anti-Integrin alpha V beta 3 antibody [23C6] (ab134488)
![Flow Cytometry - Biotin Anti-Integrin alpha V beta 3 antibody [23C6] (ab134488)](https://www.abcam.com/ps/products/134/ab134488/Images/CD51-CD61-Primary-antibodies-ab134488-1.JPG "Flow Cytometry - Biotin Anti-Integrin alpha V beta 3 antibody [23C6] (ab134488)")
Key features and details
- Biotin Mouse monoclonal [23C6] to Integrin alpha V beta 3
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
Overview
-
Product name
Biotin Anti-Integrin alpha V beta 3 antibody [23C6]
See all Integrin alpha V beta 3 primary antibodies -
Description
Biotin Mouse monoclonal [23C6] to Integrin alpha V beta 3 -
Host species
Mouse -
Conjugation
Biotin -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
The details of the immunogen for this antibody are not available.
-
Positive control
- M21 cells.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. Do Not Freeze. Store In the Dark. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.1% Gelatin, PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
23C6 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
-
Alternative Versions
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab134488 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Use 1µg for 105-8 cells.
ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Notes |
|---|
|
Flow Cyt
Use 1µg for 105-8 cells. ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Target
-
Relevance
Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733). Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. -
Cellular localization
Cell Membrane. Cytoplasmic. Integrin complex. Focal adhesion. -
Database links
- Entrez Gene: 3685 Human
- Entrez Gene: 3690 Human
- Omim: 173470 Human
- Omim: 193210 Human
- SwissProt: P05106 Human
- SwissProt: P06756 Human
- Unigene: 436873 Human
-
Alternative names
- Antigen identified by monoclonal antibody L230 antibody
- CD 51 antibody
- CD 61 antibody
see all
Images
-
Flow Cytometry - Biotin Anti-Integrin alpha V beta 3 antibody [23C6] (ab134488)
Flow cytometric analysis of total viable M21 cells labelling Integrin alpha V beta 3 with ab134488 (filled histogram) at 0.5 µg or with 0.5 µg of Mouse IgG1 kappa Isotype Control (open histogram), followed by Streptavidin PE.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab134488 has not yet been referenced specifically in any publications.