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RecombinantRabMAb

Recombinant Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)

  • Datasheet
  • Certificate of Compliance
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)
  • Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Biotin Rabbit monoclonal [EP929Y] to Ionotropic glutamate receptor 2 + 3
  • Suitable for: IHC-P
  • Reacts with: Human
  • Conjugation: Biotin

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Overview

  • Product name

    Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y]
    See all Ionotropic glutamate receptor 2 + 3 primary antibodies
  • Description

    Biotin Rabbit monoclonal [EP929Y] to Ionotropic glutamate receptor 2 + 3
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • IHC-P: FFPE human hippocampus (normal) tissue sections.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. Store In the Dark.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EP929Y
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • AMPA / Kainate

Associated products

  • Alternative Versions

    • Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] - BSA and Azide free (ab247334)
    • Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab52896)
  • Isotype control

    • Biotin Rabbit IgG - Isotype Control (ab200208)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab201534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
All applications
Mouse
Rat
Application Abreviews Notes
IHC-P
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Notes
IHC-P
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    Ion channels activated by glutamate are typically divided into two classes. Those sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). AMPAR are comprised of four distinct Glutamate Receptor Subunits (GluR1-4) and they play key roles in almost all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory.
  • Cellular localization

    Cell Membrane; multi-pass membrane protein.
  • Database links

    • Entrez Gene: 2891 Human
    • Entrez Gene: 2892 Human
    • Entrez Gene: 14800 Mouse
    • Entrez Gene: 29627 Rat
    • Omim: 138247 Human
    • Omim: 305915 Human
    • SwissProt: P42262 Human
    • SwissProt: P42263 Human
    • SwissProt: P23819 Mouse
    • SwissProt: Q4LG64 Mouse
    • SwissProt: Q80VM6 Mouse
    • SwissProt: P19491 Rat
    • Unigene: 32763 Human
    • Unigene: 377070 Human
    see all
  • Alternative names

    • AMPA selective glutamate receptor 2 antibody
    • AMPA selective glutamate receptor 3 antibody
    • GluR K2 antibody
    • GluR K3 antibody
    • GLURB antibody
    • GLURC antibody
    • GLUTAMATE RECEPTOR 2 antibody
    • GLUTAMATE RECEPTOR 3 antibody
    • Glutamate receptor ionotropic AMPA 2 antibody
    • Glutamate receptor ionotropic AMPA 3 antibody
    • GRIA2 antibody
    • GRIA3 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)

    IHC image of Ionotropic glutamate receptor 2 + 3 staining in a section of formalin-fixed paraffin-embedded normal human hippocampus tissue, performed on a Leica BondTM. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins, before blocking of endogenous biotin using ab64212. The section was then incubated with ab201534, 1/500 dilution, for 15 mins at room temperature and detected using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

  • Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)
    Biotin Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab201534)

Protocols

  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet

    Certificate of Compliance

    To download a Certificate of Compliance, please enter your Lot number below:

  • References (0)

    Publishing research using ab201534? Please let us know so that we can cite the reference in this datasheet.

    ab201534 has not yet been referenced specifically in any publications.

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