Biotin Anti-Lipoprotein a antibody (ab27631)
Key features and details
- Biotin Sheep polyclonal to Lipoprotein a
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-Lipoprotein a antibody
See all Lipoprotein a primary antibodies -
Description
Biotin Sheep polyclonal to Lipoprotein a -
Host species
Sheep -
Conjugation
Biotin -
Specificity
Thsi antibody specifically binds to human Lipoprotein a. -
Species reactivity
Reacts with: Human -
Immunogen
Full length native Lipoprotein a protein (purified) (Human)
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General notes
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 0.2% PBS, 0.435% Sodium chloride -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
Purified by a human plasminogen-Sepharose affinity column to remove cross-reactivity to plasminogen, followed by a Apolipoprotein A-Sepharose affinity column. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
Target
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Relevance
Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis. -
Database links
- Entrez Gene: 4018 Human
- Omim: 152200 Human
- SwissProt: P08519 Human
- Unigene: 520120 Human
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Alternative names
- AK38 antibody
- Antiangiogenic AK38 protein antibody
- apo(a) antibody
see all
Datasheets and documents
References (0)
ab27631 has not yet been referenced specifically in any publications.
