Key features and details
- Biotin Mouse monoclonal [PM-2K] to Macrophage
- Reacts with: Cow, Cat, Dog, Human, Pig, Monkey
- Conjugation: Biotin
- Isotype: IgG1
Product nameBiotin Anti-Macrophage antibody [PM-2K]
See all Macrophage primary antibodies
DescriptionBiotin Mouse monoclonal [PM-2K] to Macrophage
SpecificityDoes not recognize Macrophage Scavenger Receptor AI or AII as determined using positive CHO cells.
Species reactivityReacts with: Cow, Cat, Dog, Human, Pig, Monkey
Does not react with: Rat, Rabbit, Goat, Horse, Guinea pig, Hamster
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.05% KATHON™ CG/ICP
Constituents: 99% PBS, 0.5% BSA
Concentration information loading...
RelevanceMacrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and promonocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becomming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Among cells that are now recognised as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).
- macrophages antibody
ab177226 has been referenced in 1 publication.
- Zhang H et al. Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer. Blood 122:1105-13 (2013). PubMed: 23757729