Key features and details
- Biotin Mouse monoclonal [3B6] to Mannan Binding Lectin/MBL
- Suitable for: Sandwich ELISA
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
Product nameBiotin Anti-Mannan Binding Lectin/MBL antibody [3B6]
See all Mannan Binding Lectin/MBL primary antibodies
DescriptionBiotin Mouse monoclonal [3B6] to Mannan Binding Lectin/MBL
ab191898 is specific for Mannan Binding Lectin/MBL from Human serum or plasma.
Tested applicationsSuitable for: Sandwich ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Cynomolgus monkey, Gorilla, Common marmoset, Orangutan
Full length native protein (purified) corresponding to Human Mannan Binding Lectin/MBL aa 21-248. Mannan Binding Lectin purified from Human donor plasma.
ETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQ GPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAE NGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDE DCVLLLKNGQWNDVPCSTSHLAVCEFPI
Database link: P11226
EpitopeThe epitope is on the head-neck region of the MBL protein chain.
This product was previously labelled as Mannan Binding Lectin
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: 99% PBS, 0.81% Sodium chloride
Concentration information loading...
Light chain typekappa
Our Abpromise guarantee covers the use of ab191898 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Sandwich ELISA||Use at an assay dependent concentration.
ab23457 may be used as the capture and ab191898 as the detection antibody.
FunctionCalcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Tissue specificityPlasma protein produced mainly in the liver.
Involvement in diseaseNote=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.
Sequence similaritiesContains 1 C-type lectin domain.
Contains 1 collagen-like domain.
- Information by UniProt
- COLEC 1 antibody
- COLEC1 antibody
- Collectin-1 antibody
Calibration curve for Mannan Binding Lectin/MBL using ab23457 as the capture antibody and ab191898 as the detection antibody.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab191898 has not yet been referenced specifically in any publications.