Biotin Anti-MD2 antibody [18H10] (ab155580)
Key features and details
- Biotin Mouse monoclonal [18H10] to MD2
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG2b
Overview
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Product name
Biotin Anti-MD2 antibody [18H10]
See all MD2 primary antibodies -
Description
Biotin Mouse monoclonal [18H10] to MD2 -
Host species
Mouse -
Conjugation
Biotin -
Specificity
ab155580 does not react with sMD2. In addition, the monoclonal antibody 18H10 is able to inhibit bacterial binding to MD2. -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
This product was produced with the following immunogens:
Fusion protein corresponding to Human MD2.
Tissue, cells or virus corresponding to Human MD2. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
18H10 -
Isotype
IgG2b -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155580 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
ab18418 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
| Notes |
|---|
|
Flow Cyt
Use at an assay dependent concentration. ab18418 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Target
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Function
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS. -
Post-translational
modificationsN-glycosylated; high-mannose. -
Cellular localization
Secreted > extracellular space. - Information by UniProt
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Database links
- Entrez Gene: 23643 Human
- Omim: 605243 Human
- SwissProt: Q9Y6Y9 Human
- Unigene: 726603 Human
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Alternative names
- ESOP 1 antibody
- ESOP-1 antibody
- ESOP1 antibody
see all
Datasheets and documents
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Datasheet download
References (11)
ab155580 has been referenced in 11 publications.
- Morgan HL et al. Low protein diet and methyl-donor supplements modify testicular physiology in mice. Reproduction 159:627-641 (2020). PubMed: 32163913
- Kluth O et al. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans. Cell Rep 26:3027-3036.e3 (2019). PubMed: 30865891
- Sullivan B et al. On the nature of the Cu-rich aggregates in brain astrocytes. Redox Biol 11:231-239 (2017). PubMed: 28012438
- Wilkinson RD et al. A bioavailable cathepsin S nitrile inhibitor abrogates tumor development. Mol Cancer 15:29 (2016). PubMed: 27097645
- Li J et al. Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. Mol Cell Biol 35:4069-82 (2015). PubMed: 26391955
