Biotin Anti-Natriuretic peptides A antibody (ab47847)
Key features and details
- Biotin Rabbit polyclonal to Natriuretic peptides A
- Suitable for: ELISA, IP, RIA
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-Natriuretic peptides A antibody
See all Natriuretic peptides A primary antibodies -
Description
Biotin Rabbit polyclonal to Natriuretic peptides A -
Host species
Rabbit -
Conjugation
Biotin -
Tested applications
Suitable for: ELISA, IP, RIAmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
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Immunogen
Synthetic peptide corresponding to Human Natriuretic peptides A aa 124-151 conjugated to keyhole limpet haemocyanin.
Sequence:SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Database link: P01160 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab47847 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| RIA |
Use at an assay dependent concentration.
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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RIA
Use at an assay dependent concentration. |
Target
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Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
Involvement in disease
Atrial standstill 2
Atrial fibrillation, familial, 6 -
Sequence similarities
Belongs to the natriuretic peptide family. -
Post-translational
modificationsCleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 281355 Cow
- Entrez Gene: 608289 Dog
- Entrez Gene: 4878 Human
- Entrez Gene: 230899 Mouse
- Entrez Gene: 397496 Pig
- Entrez Gene: 24602 Rat
- Omim: 108780 Human
- SwissProt: Q9GLD0 Cat
see all -
Alternative names
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab47847 has not yet been referenced specifically in any publications.