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    biotin-prealbumin-antibody-ab48323.pdf

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Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Tangles & Tau
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Biotin Anti-Prealbumin antibody (ab48323)

  • Datasheet
  • SDS
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Key features and details

  • Biotin Rabbit polyclonal to Prealbumin
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

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Conjugation
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Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link® (ab201795)
Protein
Product image
Recombinant Human Prealbumin protein (ab92931)

View more associated products

Overview

  • Product name

    Biotin Anti-Prealbumin antibody
    See all Prealbumin primary antibodies
  • Description

    Biotin Rabbit polyclonal to Prealbumin
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Specificity

    This antibody is specific for Prealbumin.
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native Prealbumin (purified from plasma) (Human).

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.50
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Tangles & Tau
    • Cardiovascular
    • Blood
    • Serum Proteins

Associated products

  • Isotype control

    • Biotin Rabbit IgG - Isotype Control (ab200208)
  • Recombinant Protein

    • Recombinant Human Prealbumin protein (ab92931)

Target

  • Function

    Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
  • Tissue specificity

    Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
  • Involvement in disease

    Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.
    Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.
    Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.
  • Sequence similarities

    Belongs to the transthyretin family.
  • Domain

    Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.
  • Cellular localization

    Secreted. Cytoplasm.
  • Target information above from: UniProt accession P02766 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 7276 Human
    • Omim: 176300 Human
    • SwissProt: P02766 Human
    • Unigene: 427202 Human
    • Alternative names

      • Amyloid polyneuropathy antibody
      • Amyloidosis I antibody
      • ATTR antibody
      • Carpal tunnel syndrome 1 antibody
      • CTS antibody
      • CTS1 antibody
      • Dysprealbuminemic euthyroidal hyperthyroxinemia antibody
      • Dystransthyretinemic hyperthyroxinemia antibody
      • Epididymis luminal protein 111 antibody
      • HEL111 antibody
      • HsT2651 antibody
      • PALB antibody
      • Prealbumin amyloidosis type I antibody
      • Prealbumin antibody
      • Prealbumin Thyroxine-binding antibody
      • Senile systemic amyloidosis antibody
      • TBPA antibody
      • Thyroxine binding prealbumin antibody
      • Transthyretin antibody
      • TTHY_HUMAN antibody
      • TTR antibody
      • TTR protein antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab48323? Please let us know so that we can cite the reference in this datasheet.

    ab48323 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Question

    IP with purified human prealbumin
    used avidin-sepharose beads
    dilutions: 1/100, 1/10, 1/1
    glycine to elute beads
    detection: SDS-PAGE with total protein (nice band), flow thru, washes, pre and post elution
    no protein band seen after IP!

    Read More

    Abcam community

    Verified customer

    Asked on Apr 03 2012

    Answer

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    Answered on Apr 03 2012

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