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Cardiovascular Blood Fibrinolysis / Thrombolysis
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Biotin Anti-Protein S antibody (ab105368)

  • Datasheet
  • SDS
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Key features and details

  • Biotin Rabbit polyclonal to Protein S
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

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Overview

  • Product name

    Biotin Anti-Protein S antibody
    See all Protein S primary antibodies
  • Description

    Biotin Rabbit polyclonal to Protein S
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Human Protein S purified from Human plasma.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.50
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Blood
    • Fibrinolysis / Thrombolysis
    • Cardiovascular
    • Blood
    • Serum Proteins
    • Cardiovascular
    • Blood
    • Coagulation
    • Regulatory
    • Kits/ Lysates/ Other
    • Kits
    • ELISA Kits
    • ELISA Kits
    • Cardiovascular ELISA kits

Associated products

  • Isotype control

    • Biotin Rabbit IgG - Isotype Control (ab200208)
  • Recombinant Protein

    • Recombinant Human Protein S (ab159231)

Target

  • Function

    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • Tissue specificity

    Plasma.
  • Involvement in disease

    Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
  • Sequence similarities

    Contains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • Post-translational
    modifications

    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P07225 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 5627 Human
    • Omim: 176880 Human
    • SwissProt: P07225 Human
    • Unigene: 64016 Human
    • Alternative names

      • Preproprotein S antibody
      • Propiece of latent protein S antibody
      • PROS 1 antibody
      • PROS antibody
      • PROS_HUMAN antibody
      • proS1 antibody
      • Protein S alpha antibody
      • Protein Sa antibody
      • PS 21 antibody
      • PS 22 antibody
      • PS 23 antibody
      • PS 24 antibody
      • PS 25 antibody
      • PS 26 antibody
      • PS21 antibody
      • PS22 antibody
      • PS23 antibody
      • PS24 antibody
      • PS25 antibody
      • PS26 antibody
      • PSA antibody
      • THPH5 antibody
      • THPH6 antibody
      • Vitamin K dependent protein S antibody
      • Vitamin K-dependent plasma protein S antibody
      • Vitamin K-dependent protein S antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab105368? Please let us know so that we can cite the reference in this datasheet.

    ab105368 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    ELISA abreview for Anti-Protein S antibody (Biotin)

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    ELISA
    Sample
    Human Cell (human macrophages)
    Specification
    human macrophages
    Type
    Sandwich (Detection)
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 08 2014

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