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Neuroscience Cell Adhesion Proteins ECM Proteins
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Biotin Anti-SIRP alpha antibody [OX-41] (ab33987)

  • Datasheet
  • SDS
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Key features and details

  • Biotin Mouse monoclonal [OX-41] to SIRP alpha
  • Reacts with: Rat
  • Conjugation: Biotin
  • Isotype: IgG2a

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Overview

  • Product name

    Biotin Anti-SIRP alpha antibody [OX-41]
    See all SIRP alpha primary antibodies
  • Description

    Biotin Mouse monoclonal [OX-41] to SIRP alpha
  • Host species

    Mouse
  • Conjugation

    Biotin
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Peritoneal macrophages (Rat)

  • Epitope

    This clone binds to a different epitope on CD172a than ED 9.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: 1% BSA
  • Concentration information loading...
  • Clonality

    Monoclonal
  • Clone number

    OX-41
  • Isotype

    IgG2a
  • Research areas

    • Neuroscience
    • Cell Adhesion Proteins
    • ECM Proteins
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Synapse marker
    • Cardiovascular
    • Atherosclerosis
    • Vascular Inflammation
    • Inflammatory mediators

Associated products

  • Alternative Versions

    • FITC Anti-SIRP alpha antibody [OX-41] (ab34076)
  • Isotype control

    • Biotin Mouse IgG2a, kappa [MOPC-173] - Isotype Control (ab18454)
  • Recombinant Protein

    • Recombinant human SIRP alpha protein (Fc Chimera Active) (ab221342)

Applications

  • Application notes
    Flow Cyt: Use neat. Use 10ul to label 106 cells in 100ul.
    IHC-Fr: Use at an assay dependent dilution.
    IHC-P: Use at an assay dependent dilution. This product requires protein digestion pre-treatment of paraffin sections, eg.trypsin or pronase.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
    • Tissue specificity

      Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
    • Sequence similarities

      Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications

      N-glycosylated.
      Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P78324 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 25528 Rat
      • SwissProt: P97710 Rat
      • Unigene: 53971 Rat
      • Alternative names

        • Signal regulatory protein alpha type 1 antibody
        • Bit antibody
        • Brain Ig like molecule with tyrosine based activation motifs antibody
        • Brain Ig-like molecule with tyrosine-based activation motifs antibody
        • Brain immunoglobulin like molecule with tyrosine based activation motifs antibody
        • CD172 antigen like family member A antibody
        • CD172 antigen-like family member A antibody
        • CD172a antibody
        • CD172a antigen antibody
        • Inhibitory receptor SHPS-1 antibody
        • Macrophage fusion receptor antibody
        • MFR antibody
        • MYD 1 antibody
        • Myd 1 antigen antibody
        • MyD-1 antigen antibody
        • p84 antibody
        • Protein tyrosine phosphatase non receptor type substrate 1 antibody
        • PTPNS1 antibody
        • SHP substrate 1 antibody
        • SHPS-1 antibody
        • SHPS1 antibody
        • SHPS1_HUMAN antibody
        • Signal regulatory protein alpha 2 antibody
        • Signal regulatory protein alpha 3 antibody
        • Signal regulatory protein alpha antibody
        • Signal regulatory protein alpha type 2 antibody
        • Signal-regulatory protein alpha-1 antibody
        • Signal-regulatory protein alpha-2 antibody
        • Signal-regulatory protein alpha-3 antibody
        • SIRP antibody
        • Sirp-alpha-1 antibody
        • Sirp-alpha-2 antibody
        • Sirp-alpha-3 antibody
        • SIRPA antibody
        • SIRPalpha antibody
        • SIRPalpha1 antibody
        • SIRPalpha2 antibody
        • SIRPalpha3 antibody
        • Tyrosine phosphatase SHP substrate 1 antibody
        • Tyrosine protein phosphatase non receptor type substrate 1 antibody
        • Tyrosine-protein phosphatase non-receptor type substrate 1 antibody
        see all

      Protocols

      • Flow cytometry protocols
      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (2)

      Publishing research using ab33987? Please let us know so that we can cite the reference in this datasheet.

      ab33987 has been referenced in 2 publications.

      • Adams S  et al. Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 161:1853-9 (1998). PubMed: 9712053
      • Robinson AP  et al. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology 57:239-47 (1986). PubMed: 3512425

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