Biotin Anti-sRANKL antibody (ab83436)

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Key features and details

  • Biotin Goat polyclonal to sRANKL
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

Overview

  • Product name

    Biotin Anti-sRANKL antibody
    See all sRANKL primary antibodies

  • Description

    Biotin Goat polyclonal to sRANKL

  • Host species

    Goat

  • Conjugation

    Biotin

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Highly pure (>98%) recombinant human sRANKL

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

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Properties

Target

  • Function

    Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

  • Tissue specificity

    Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

  • Involvement in disease

    Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.

  • Sequence similarities

    Belongs to the tumor necrosis factor family.

  • Post-translational
    modifications

    The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.

  • Cellular localization

    Cytoplasm; Secreted and Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD254 antibody
      • hRANKL2 antibody
      • ODF antibody
      • OPGL antibody
      • OPTB2 antibody
      • Osteoclast differentiation factor antibody
      • Osteoprotegerin ligand antibody
      • RANKL antibody
      • Receptor activator of NF-kappa-B ligand antibody
      • Receptor activator of nuclear factor kappa B ligand antibody
      • Receptor activator of nuclear factor kappa-B ligand antibody
      • sOdf antibody
      • soluble form antibody
      • TNF-related activation-induced cytokine antibody
      • TNF11_HUMAN antibody
      • Tnfsf11 antibody
      • TRANCE antibody
      • Tumor necrosis factor (ligand) superfamily member 11 antibody
      • Tumor necrosis factor ligand superfamily member 11 antibody
      see all

    References (0)

    Publishing research using ab83436? Please let us know so that we can cite the reference in this datasheet.

    ab83436 has not yet been referenced specifically in any publications.

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