Biotin Anti-Urokinase antibody (ab49577)
Key features and details
- Biotin Rabbit polyclonal to Urokinase
- Suitable for: ELISA, IP, RIA, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Overview
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Product name
Biotin Anti-Urokinase antibody
See all Urokinase primary antibodies -
Description
Biotin Rabbit polyclonal to Urokinase -
Host species
Rabbit -
Conjugation
Biotin -
Tested applications
Suitable for: ELISA, IP, RIA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length native ATF uPA purified from plasma (Human)
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General notes
ATF is the amino terminal fragment of urokinase (uPA) corresponding to amino acid residues 1-135. uPA-ATF contains the growth factor like domain, which binds to the urokinase receptor, and the kringle domain which is involved in the induction of cell chemotaxis by urokinase. ATF inhibits the binding of urokinase to its receptor uPAR and acts as a broad inhibitor of cell migration.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol -
Concentration information loading... -
Purity
Protein G purified -
Primary antibody notes
ATF is the amino terminal fragment of urokinase (uPA) corresponding to amino acid residues 1-135. uPA-ATF contains the growth factor like domain, which binds to the urokinase receptor, and the kringle domain which is involved in the induction of cell chemotaxis by urokinase. ATF inhibits the binding of urokinase to its receptor uPAR and acts as a broad inhibitor of cell migration. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab49577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| RIA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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RIA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
Target
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Function
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. -
Tissue specificity
Expressed in the prostate gland and prostate cancers. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain. -
Post-translational
modificationsPhosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 5328 Human
- Omim: 191840 Human
- SwissProt: P00749 Human
- Unigene: 77274 Human
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Alternative names
- ATF antibody
- ATF uPA antibody
- BDPLT5 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab49577 has not yet been referenced specifically in any publications.