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    biotin-vaccinia-virus-antibody-ab21039.pdf

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Microbiology Organism Virus DNA Virus double stranded DNA Virus Other dsDNA viruses
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Biotin Anti-Vaccinia Virus antibody (ab21039)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (2)

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Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Key features and details

  • Biotin Rabbit polyclonal to Vaccinia Virus
  • Suitable for: ELISA
  • Reacts with: Vaccinia virus
  • Conjugation: Biotin
  • Isotype: IgG

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Overview

  • Product name

    Biotin Anti-Vaccinia Virus antibody
    See all Vaccinia Virus primary antibodies
  • Description

    Biotin Rabbit polyclonal to Vaccinia Virus
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Vaccinia virus
  • Immunogen

    Lister Strain (mixture of virions and infected cell polypeptides).

  • General notes

    The antibody is covalently coupled with the N-Hydroxysuccinimide ester of biotin under mild conditions to give a high degree of substitution.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 0.0268% PBS
  • Concentration information loading...
  • Purity

    IgG fraction
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Microbiology
    • Organism
    • Virus
    • DNA Virus
    • double stranded DNA Virus
    • Other dsDNA viruses

Associated products

  • Isotype control

    • Biotin Rabbit IgG - Isotype Control (ab200208)

Applications

Our Abpromise guarantee covers the use of ab21039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • Relevance

    Vaccinia virus is an Orthopoxvirus, containing double stranded DNA. Fusion protein plays an important role in the entry of enveloped virus into cells. As vaccinia virus has a wide host range, it is conceivable that certain cellular components that are ubiquitously expressed on the cell mediate virus infection. The study of the entry process, attachment, fusion and the proteins and receptors involved is complex. During vaccinia virus infection, the fusion process is attributed to the action of the 14KDa protein (A27L). The N terminus of this protein recognises heparan sulfate on the cell surface. It interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this 14KDa protein are able to neutralize vaccinia virus infection and enable identification other viral and cellular proteins which participate in the vaccinia virus entry process.
  • Alternative names

    • A27L antibody
    • Orthopoxvirus antibody

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (2)

    Publishing research using ab21039? Please let us know so that we can cite the reference in this datasheet.

    ab21039 has been referenced in 2 publications.

    • Kim JS  et al. The resveratrol analogue, HS-1793, enhances the effects of radiation therapy through the induction of anti-tumor immunity in mammary tumor growth. Int J Oncol 56:1405-1416 (2020). PubMed: 32236622
    • Ylösmäki E  et al. Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses. Mol Ther 26:2315-2325 (2018). PubMed: 30005865

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    What antigens do you anti-vaccinia antibodies detect? I need one that will detect the H3L envelope gene.

    Read More

    Abcam community

    Verified customer

    Asked on Dec 16 2005

    Answer

    Thank you for your enquiry. Ab21098 - Mouse monoclonal [TV46] to Vaccinia Virus - reacts with a 27 kDa protein and is weakly reactive with 57 kDa and 6 1kDa proteins in Western blot. The identity of the proteins have not been determined. Ab21039 - Rabbit polyclonal to Vaccinia Virus (Biotin) - is a polyclonal antibody and will detect multiple epitopes. The individual proteins have not been identified. This antibody reacts to Lister, Wyeth, New York City and MVA strains of Vaccinia virus. Ab20041 is no longer available as part of our catalog. Please contact us again if you have any additional questions.

    Read More

    Abcam Scientific Support

    Answered on Dec 20 2005

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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