Overview

  • Product name

    Biotin-VAD-FMK, pan-caspase inhibitor
  • Description

    Pan-caspase inhibitor
  • Biological description

    Irreversible, pancaspase inhibitor. Inhibits TNFα-mediated apoptosis in vitro (IC50 = 0.7 μM). Immunosuppressive, inhibits T cell proliferation. Active in vivo and in vitro. Cell-permeable.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    672.81
  • Molecular formula

    C30H49FN6O8S
  • Sequence

    VAD (Modifications: N-terminal biotinyl; C-terminal FMK; Asp-3 = Asp(OMe))
  • PubChem identifier

    44135213
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lawrence CP & Chow SC Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol 265:103-12 (2012). Read more (PubMed: 22982538) »
  • Equils O  et al. Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect Dis Obstet Gynecol 2009:749432 (2009). Read more (PubMed: 20069051) »
  • Cowburn AS  et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood 105:2970-2 (2005). Read more (PubMed: 15572588) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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