Bioymifi, death receptor 5 (DR5) activator (ab219580)

Overview

  • Product name
    Bioymifi, death receptor 5 (DR5) activator
  • Description
    Novel, potent, selective death receptor 5 (DR5) activator
  • Alternative names
    • DR5 Activator
  • Biological description

    Novel, potent, selective death receptor 5 (DR5) activator. Mimics the ability of TRAIL, the natural DR5 ligand, to stimulate clustering of DR5, triggering apoptosis. Binds selectively to the extracellular domain of DR5 (Kd = 1.2 µM). Causes apoptosis and cell death in a variety of human cancer cell lines, including T98G human glioblastoma cells, lung cancer cell lines H460 and H1155, the cervical cancer cell line HeLa, the osteosarcoma cell line U2OS, the pancreatic carcinoma cell line Miapaca and the colon cancer cell line HT29. 

  • Purity
    > 98%

Properties

  • Chemical name
    (Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
  • Molecular weight
    494.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H12BrN3O4S
  • CAS Number
    1420071-30-2
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=CC=C1N2C(=O)/C(=C/C3=CC=C(O3)C4=CC5=C(C=C4)C(=O)NC5=O)/SC2=N)Br
  • Source

    Synthetic

References

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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