Biperiden hydrochloride, M1 receptor antagonist (ab141781)

Overview

  • Product name

    Biperiden hydrochloride, M1 receptor antagonist
  • Description

    Potent, selective M1 receptor antagonist
  • Biological description

    Potent, selective M1 receptor antagonist (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Shows antiparkinsonian effects and induces impairment of cognitive function in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    1235-82-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride
  • Molecular weight

    347.92
  • Molecular formula

    C21H29NO.HCl
  • PubChem identifier

    92151
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM and in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gieling E  et al. Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden. Behav Brain Funct 9:4 (2013). Read more (PubMed: 23305134) »
  • Klinkenberg I & Blokland A A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. Psychopharmacology (Berl) 215:549-66 (2011). Read more (PubMed: 21336581) »
  • Bolden C  et al. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther 260:576-80 (1992). Read more (PubMed: 1346637) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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