Bis(3,5-dibromosalicyl) fumarate, hemoglobin acylating agent (ab142836)

Overview

  • Product name

    Bis(3,5-dibromosalicyl) fumarate, hemoglobin acylating agent
  • Description

    Potent hemoglobin acylating agent. Cross-links beta chains of hemoglobin.
  • Biological description

    Potent hemoglobin acylating agent. Cross-links beta chains of hemoglobin. Acylating and anti-sickling agent. Active in vitro and in vivo.
  • Purity

    > 93%
  • CAS Number

    71337-53-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,5-Dibromo-2-[(E)-4-(2,4-dibromo-6-carboxyphenoxy)-4-oxobut-2-enoyl]oxybenzoic acid
  • Molecular weight

    671.87
  • Molecular formula

    C18H8Br4O8
  • PubChem identifier

    5997029
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C=C(C(=C1Br)OC(=O)C=CC(=O)OC2=C(C=C(C=C2C(=O)O)Br)Br)C(=O)O)Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dunne J  et al. Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochem J 399:513-24 (2006). Read more (PubMed: 16848758) »
  • Zaugg RH  et al. Modification of hemoglobin with analogs of aspirin. J Biol Chem 255:2816-21 (1980). Read more (PubMed: 7358711) »
  • Walder JA  et al. Diaspirins that cross-link beta chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate. Biochemistry 18:4265-70 (1979). Read more (PubMed: 486423) »

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