Overview

  • Product name

    Bisacodyl, Na+/K+-ATPase inhibitor
  • Description

    Na+/K+-ATPase inhibitor
  • Biological description

    Na+/K+-ATPase inhibitor. Increases mucosal PG2E levels. Stimulates adenylyl cyclase activity. Stimulates enteric nerves and selectively increases lower intestinal motility. Shows laxative effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    603-50-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [4-[(4-Acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
  • Molecular weight

    361.39
  • Molecular formula

    C22H19NO4
  • PubChem identifier

    2391
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ikarashi N  et al. The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect. Eur J Pharm Sci 45:73-8 (2012). Read more (PubMed: 22085681) »
  • Fabri RL  et al. In-vivo laxative and toxicological evaluation and in-vitro antitumour effects of Mitracarpus frigidus aerial parts. J Pharm Pharmacol 64:439-48 (2012). Read more (PubMed: 22309276) »
  • Ikarashi N  et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol 301:G887-95 (2011). Read more (PubMed: 21868635) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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