Bisindolylmaleimide II, PKC inhibitor (ab144206)

Overview

  • Product name

    Bisindolylmaleimide II, PKC inhibitor
  • Description

    Potent, selective ATP-competitive PKC inhibitor. Potent noncompetitive nAChR antagonist.
  • Biological description

    Potent, selective ATP-competitive PKC inhibitor (IC50 values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC50 = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects.
  • Purity

    > 97%
  • CAS Number

    137592-45-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(1H-Indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione
  • Molecular weight

    438.52
  • Molecular formula

    C27H26N4O2
  • PubChem identifier

    2397
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
  • Source

    Synthetic

References

This product has been referenced in:

  • Macías A  et al. PKC inhibition results in a Kv 1.5 + Kv ß1.3 pharmacology closer to Kv 1.5 channels. Br J Pharmacol 171:4914-26 (2014). Read more (PubMed: 24946104) »
  • Quinlan LR  et al. Phospholipase C and protein kinase C involvement in mouse embryonic stem-cell proliferation and apoptosis. Reproduction 126:121-31 (2003). Read more (PubMed: 12814354) »
  • Mahata M  et al. Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells. Mol Pharmacol 61:1340-7 (2002). Read more (PubMed: 12021395) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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