Key features and details
- Potent cell-permeable PKC inhibitor
- CAS Number: 119139-23-0
- Purity: > 98%
- Soluble ethanol to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameBisindolylmaleimide IV, PKC inhibitor
DescriptionPotent cell-permeable PKC inhibitor
Biological descriptionPotent cell-permeable PKC inhibitor (IC50 values are 0.1 - 0.55 μM). Inhibits PKA (IC50 values are 2 - 11.8 µM). Noncompetitive nAChR antagonist. Shows less potent antinicotinic effects than Bisindolylmaleimide II (ab144206). Induces apoptosis and shows antiproliferative effects.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble ethanol to 50 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144208 has not yet been referenced specifically in any publications.