Bisindolylmaleimide VIII acetate, PKC inhibitor (ab143782)

Overview

  • Product name

    Bisindolylmaleimide VIII acetate, PKC inhibitor
  • Description

    Potent, selective protein kinase C (PKC) inhibitor.
  • Alternative names

    • 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Acetic Acid Salt
    • BIM VIII
    • Bis VIII
    • Bisindolylmaleimide VIII Acetic Acid Salt
    • Ro 31-7549 Acetic Acid Salt
    • Ro 31-7549/001 Acetic Acid Salt
    see all
  • Biological description

    Potent, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC). Facilitates Fas-mediated apoptosis through a protein kinase C-independent mechanism and inhibits T cell-mediated autoimmune diseases.

  • CAS Number

    138516-31-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-)-1H-pyrrole-2,5-dione acetate

  • Molecular weight

    458.51
  • Molecular formula

    C24H22N4O2.CH3CO2H
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Zhou T  et al. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Nat Med 5:42-8 (1999). Read more (PubMed: 9883838) »
  • Zhang C  et al. Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways. J Immunol 158:4968-75 (1997). Read more (PubMed: 9144516) »
  • Wilkinson SE  et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294 ( Pt 2):335-7 (1993). Read more (PubMed: 8373348) »

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