Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor (ab144211)

Overview

  • Product name

    Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor
  • Description

    Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor
  • Biological description

    Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).
  • Purity

    > 98%
  • CAS Number

    145317-11-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione hydrochloride
  • Molecular weight

    460.96
  • Molecular formula

    C26H24N4O2.HCl
  • PubChem identifier

    11539879
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Ghosh AK Regulation by prostaglandin E2 and histamine of angiogenesis in inflammatory granulation tissue. Yakugaku Zasshi 123:295-303 (2003). Read more (PubMed: 12772586) »
  • Sullivan JA  et al. Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils. Eur J Immunol 24:621-6 (1994). Read more (PubMed: 8125132) »
  • Muid RE  et al. A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli. FEBS Lett 293:169-72 (1991). Read more (PubMed: 1660001) »

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