Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor (ab144211)
Overview
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Product name
Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor -
Description
Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor -
Biological description
Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374). -
Purity
> 98% -
CAS Number
145317-11-9 -
Chemical structure
Properties
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Chemical name
3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione hydrochloride -
Molecular weight
460.96 -
Molecular formula
C26H24N4O2.HCl -
PubChem identifier
11539879 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN.Cl -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab144211 has not yet been referenced specifically in any publications.
